Pharmacogenetic Testing (PGx)

Pharmacogenetics is the study of the role that inheritance plays in individual variation to drug response. Understanding the influence of heritability on an individual’s drug metabolism offers the potential to identify which drug, and at what dose, is likely to be safest and most effective for a particular individual, which helps medical practitioners improve patient outcomes as well as reduce adverse drug events (ADEs).

Currently, the majority of medicines are taken in dosages determined by patient age (pediatric versus adult), weight, and other clinical factors. In many instances, these criteria prove inadequate in ensuring that a medication will be safe and effective for a particular individual. Pharmacogenetics promises to take some of the the guesswork out of prescribing safe and effective drugs.

While a number of variables influence how medications affect individuals, clinical evidence suggests that genetics may explain a significant percentage of the variability in medication effects, such as poor response or serious adverse drug reactions (ADRs). As a result, the ability to predict how a patient will respond to a specific drug through pharmacogenetic testing can have a dramatic impact on patient care and quality of life.

Companies can now analyze your DNA and see which of your biochemical pathways may be impaired because of a genetic polymorphism. These alterations in enzyme function and corresponding metabolic action are categorized into four phenotypes.
 
  • Poor Metabolizers
  • Intermediate Metabolizers
  • Extensive Metabolizers
  • Ultra-Rapid Metabolizers
They then cross-reference these personal classifications with all prescribed medications that require that pathway to break them down.

At present, over 770,000 injuries or deaths occur due to drug reactions per year in theUnited States. Pharmacogenetics promises to significantly lowering this number.

Insurance companies, who pay for drugs, are starting to recognize the therapeutic value and cost savings of such tests, and will often pay for the analysis, because:

*If a screening indicates you won’t benefit from a medication, you can avoid the expense of buying it.
*If a screening helps you avoid bad reactions to drugs, you may also avoid expensive hospitalization or emergency room visits.
With the help of personalized medicine, and our physician partnership network, we’re shifting the health care management paradigm to focus on prevention, moving from illness to wellness, and from treating disease to maintaining health.

By improving our physicians’ ability to predict and account for individual differences in disease diagnosis, experience, and therapy response, personalized medicine offers hope for diminishing the duration and severity of illness, shortening product development timelines, and improving success rates. Pharmogenetics may also reduce healthcare costs by improving our physicians’ ability to quickly and reliably select effective therapy for a given patient, while minimizing costs associated with ineffective treatment and avoidable adverse events.

Why Pharmacogenetic Testing?

Provides evidence- based, actionable data to assist healthcare practitioners with effective treatment and therapy
Offer risk mitigation for practices
Helps to prevent adverse drug reactions in patients
Improves insight into unexpected drug monitoring results
Facilitates truly personalized medicine

Why DSC?

We offer pharmacogenetic industry-leading turn-around times of three to five days from receipt of sample
DSC delivers comprehensive testing options using state-of-the-art technology
We provide easy-to-read reports highlighting clinical significance to help guide customized therapy
DSC provides real-time genetics support for in-depth consultations
DSC offers compassionate billing